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Pethidine is swiftly hydrolysed within the liver to pethidinic acid and can also be demethylated to norpethidine, which has fifty percent the analgesic action of pethidine but a longer elimination 50 %-life (8–12 several hours);[39] accumulating with common administration, or in kidney failure. Norpethidine is poisonous and has convulsant and hal